Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors

IntroductionImmune-checkpoint inhibitors are effective in various advanced cancers.Type 1 diabetes mellitus induced by them (ICI-T1DM) is a serious complication requiring prompt insulin treatment, but the immunological mechanism behind it is unclear.MethodsWe examined amino acid polymorphisms in human histocompatibility leukocyte antigen (HLA) mole

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Four temporin-derived peptides exhibit antimicrobial and antibiofilm activities against methicillin-resistant Staphylococcus aureus

Temporin-GHa (GHa) was cloned from Hylarana guentheri, showing a weak antimicrobial activity.In order to improve its bactericidal efficacy, GHaR6R, GHaR7R, GHaR8R and 1" PROFESSIONAL HOT AIR BRUSH GHaR9W were designed and synthesized.Compared to the parent peptide, the GHa-derived peptides show potent antimicrobial activities against methicillin-re

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Moonlight Is Perceived as a Signal Promoting Genome Reorganization, Changes in Protein and Metabolite Profiles and Plant Growth

Rhythmic exposure to moonlight has been shown to affect animal behavior, but its effects on plants, often observed Inositol in lunar agriculture, have been doubted and often regarded as myth.Consequently, lunar farming practices are not well scientifically supported, and the influence of this conspicuous environmental factor, the moon, on plant cel

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Sodium-dependent vitamin C transporter 2 (SVCT2) expression and activity in brain capillary endothelial cells after transient ischemia in mice.

Expression and transport activity of Sodium-dependent Vitamin C Transporter 2 (SVCT2) was shown in various tissues and organs.Vitamin C was shown to be cerebroprotective in several animal models of stroke.Data on expression, localization and transport activity of SVCT2 after cerebral ischemia, however, has been scarce so far.Thus, Snacks we studied

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